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Hope
Michael Ellenbogen
Posted: Friday, September 13, 2019 9:30 AM
Joined: 11/30/2011
Posts: 2477


I know we all want hope but to may of us get caught up with scammers that say they have some type of cure. Don’t you think if they were true it would be on the NIH radar. I can tell you have spoke with some of the smartest folks there and they are open to any type of cure as long as it can be backed up in some way. So far there are none. Please save your money and focus on the things that do matter. I hear from all of the scammers and the list is supper long and sad hon how they try to take advantage of vulnerable people.
jfkoc
Posted: Friday, September 13, 2019 10:58 AM
Joined: 12/4/2011
Posts: 17264


Agree. We need to always be aware of "cures" and what possible side effects they may have.
Jo C.
Posted: Friday, September 13, 2019 1:40 PM
Joined: 12/9/2011
Posts: 10043


Thank you Michael; that is so true.  Some of these individuals make a veritable fortune and are very highly and smoothly advertised, with very professional, glossy looking marketing and mega touting of not only their "cure," or absolute "prevention; " but provide the substances to do so.  Beware especially when they are marketing their books and mail order of multiple OTC supplements and other wares.

Hope springs eternal and we oh, so hope.  Sometimes, when following such marketing and use of marketed wares, there may be an "improvement," seen, but alas; not really.  More attention on the person, more change in approach, can make a difference for a short bit, but not as what we fully expected when we opened our wallets.  AND . . . . not everyone falling into the marketing basket will actually have Alzheimer's Disease; as we know, one size does not fit all and not all have seen skilled demenia specialists to obtain an accurate exam and accurate diagnosis; so Alzheimer's may not even have been present.

It is true; if there were indeed a cure or absolute prevention for Alzheimer's Disease, then it would be touted not only by the NIH, it would be bombastically shouted from the rooftops of the media, by the AMA,  and by the various support associations, WHO, and so much more . 

Hang onto our pocketbooks, wallets, credit cards, and always; caveat emptor!

Thanks again,

J.


Lane Simonian
Posted: Friday, September 13, 2019 1:40 PM
Joined: 12/12/2011
Posts: 4564


I have just about given up on drug treatments for Alzheimer's disease.  They are all working on the margins and they all fail one after another.  Going after misfolded amyloid and tau proteins, receptor agonists and antagonists, enzyme activators and deactivators, reducing inflammation and so forth are only treating one aspect of the disease.  At best, drugs in these categories will only slow down the progression of the disease for awhile.

There are two quotes on Alzheimer's that I treasure.  The first is this:

Dr Carrasco and his team think a clinical trial of anti-fungal drugs is the next logical step. But there is yet another possibility. In the absence of a definitive ultimate cause, it may be that the symptoms of Alzheimer’s disease can arise from many different types of insult to the brain. There have been several papers, says Dr Le Guillou, that have found correlations between various infectious organisms and Alzheimer’s. “It could be a bit like the Mississippi river,” says Dr Hardy. “You can start in all sorts of places, but eventually you’re going to end up in New Orleans.” If Alzheimer’s is a general response to all sorts of neurological triggers then it may be that the fungal infections found by Dr Carrasco are simply one of a long list of causes.

And this is where Dr. Bredesen for whatever faults there are in the promotion of his protocol is correct: there are dozens of factors that cause Alzheimer's disease.  Lessen or reduce your exposure to them (if you can even identify all of them) and you reduce your chances of getting Alzheimer's disease and you increase your chances of effectively treating it in its very early stages.

My next favorite quote on Alzheimer's disease is this:

[Clinical trials with over-the-counter supplements have concentrated either on
items which suppress inflammation, or on antioxidants which scavenge oxygen
derived free radicals. Most of these items have proved to be worthless in the
treatment of Alzheimer’s disease. Similarly most drugs used to treat Alzheimer’s
disease do little to slow the deterioration, but instead offer a mild temporary
symptom relief. However, evidence has been accumulating that the primary driver
of Alzheimer’s disease is a nitrogen derived free radical called peroxynitrite,
which may mediate both amyloid and tau accumulation as well as their toxicity.
Excellent results have been obtained with peroxynitrite scavengers, with
reversals of Alzheimer’s disease in human clinical trials being repeatedly
demonstrated. IMHO, the only thing which may be preventing the abolition of
Alzheimer’s disease is the mental inertia of scientists, as well as the
bureaucrats who fund them. Unfortunately, most bureaucrats keep throwing money
into repeatedly testing discredited interventions, while ignoring successful
ones. Common sense is anything but…]

This is an incomplete list of peroxynitrite scavengers that have been used to treat Alzheimer's disease in clinical trials (I admit some of these trials are not well-designed).

Korean Red Ginseng

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659550/

Heat Processed Ginseng (panax ginseng steamed at higher temperatures)

https://www.ncbi.nlm.nih.gov/pubmed/22780999

Chinese herbs (including ginseng) plus conventional Alzheimer's medications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729264/

Herbal combination (including ginseng)

https://europepmc.org/abstract/med/30109588

Aromatherapy

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1479-8301.2009.00299.x

Feru-guard (ferulic acid in Angelica archangelica and rice bran oil)

https://clinicaltrials.gov/ProvidedDocs/60/NCT03451760/Prot_SAP_000.pdf

The great majority of supplements being sold for Alzheimer's disease are not likely to work because of various issues (poor absorption, don't cross the blood-brain barrier, can become pro-oxidants, not strong enough, etc.), but a few have a better chance of succeeding than any drug currently being tested for the treatment of Alzheimer's disease.



Marta
Posted: Saturday, September 14, 2019 12:50 PM
Joined: 6/3/2013
Posts: 711


If a substance is as yet undergoing testing, we do not know its efficacy, nor can we make a statement about its superiority or inferiority with respect to another substance.