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What's Your Definition of a Successful Alzheimer Drug/Treatment?
HowDoYouDeal
Posted: Friday, December 13, 2019 11:37 AM
Joined: 2/17/2019
Posts: 347


Much like the breadwinner wife who is impatiently waiting for her husband to give up the fantasy of being a musician and get a real job, its important to set a deadline.

The advice giver suggested the woman set a time frame, work with the husband to decide exactly how long is reasonable to take to try to make it big. 

 If she didn't set up hard deadlines, the goal post would just keep moving.... just one more gig... after Christmas....its the bass players birthday.....

In that spirit, what ARE your criteria for taking part, specifcally?

 Are you waiting for:

A trial to go to the Second Stage? The 3rd Stage?

Does it need to be a cure? Or will a treatment suffice?

If a treatment would be okay,  how do you determine if a treatment is successful?

Do a certain number of people need to be treated before you? If so, what is that number? 

How much improvement does the treatment need to offer?

How close does it need to be to you/How far would you be willing to travel.

How often is too often to travel for treatment? 3 x a week?  2 x? Weekly? Bi-Weekly? Once a month? Once every 6 weeks.

Would you accept an injection?

What Institution needs to support it? Is a single high ranking University Research Team enough.

Does it need to be in the news?  Which news Media: Online Newspaper? Print Newspaper?  Internet Video News Report.  TV News Report?  Which Station? How many instances?

If you keep waiting until you are convinced, but you haven't decided what it would take to convince you, you may keep putting it off, and putting it off....

 


HowDoYouDeal
Posted: Friday, December 13, 2019 11:45 AM
Joined: 2/17/2019
Posts: 347


And this is a  NORMAL  part of  HUMAN NATURE!.

 
A group of families decided to set up a Neighbourhood Watch in their area.

  • In the beginning, the biggest threats merit a call to the police.  Over time, as police visit the neighbourhood and the larger threats go away.
  • The volunteers doing the watching start to report smaller threats that they previously would have ignored: a group of loud kids in the park.. and so it goes...
  • Until one day, they find themselves calling the police on a jaywalker.
  • Unless you define what it is that you are looking for, you may find it changes over time, without you necessarily noticing
  • Its all about what you get used to......


LDDaughter
Posted: Friday, January 10, 2020 5:17 PM
Joined: 12/22/2011
Posts: 1065


Good questions.  Can't answer them all, but I think I would be biased towards successful Phase 2, Phase 3 even better, but I guess not that many Phase 3 are successful or we'd have more treatments right?.  The other bias is for repurposed drugs, meds that are already in use say for asthma for example, and have been on the market for years with very low side effects and a good safety profile.  Distance would be also be a factor.  Travel can present problems depending upon the stage.  Even in early stages there may be resistance.  I have a friend who's enrolling her husband in a study that's local in our area and it's taking a lot of arm twisting to have him participate.