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40hz light therapyTreatment and Near Infra Red light therapy Succeed in Clinical trials
HowDoYouDeal
Posted: Wednesday, April 3, 2019 8:29 AM
Joined: 2/17/2019
Posts: 177


Well it certainly is a good morning, I seem to have stumbled across two non-conventional treatments for Alzheimers that have hahd early success in clinical trials.

The 40hz clinical trials on 6 people, similar to the mouse study, did actually reduce amyloid for 2 people and 1 person had less amyloid build up than the others, the authors note that they did NOT control the amount of time the people actually spend  LOOKING at the light, it ranged from 10 minutes to 60 minutes out of a 60 minute session.

Surprise, surprise, some people got a lot better, one person had less decline, 3 declined. 

 2 Really good results + I sorta good results + 3 pretty bad results = no significant results.

Unfortunately that's the way they have to report it, but if you look at the individual results data like I did, you'll see what actually happened to each person's brain. And there were some quite good results, that's why they organized another, bigger trial.

Don't have time to post all the links now, but will after work tonight.

For Now:  the  ALZLife app and VieLight work!

 

Researchers are investigating the curious health benefits of shining light on the body, and the preliminary findings on illnesses such as Alzheimer's are nothing short of remarkable.

Published On 03/02/2017
8:30 AM EST



 

In December, a team of MIT neuroscientists published a remarkable study in which levels of harmful amyloid beta proteins were cut in half by exposing mice with early-stage Alzheimer's to flashing LED lights. No drugs, no surgery - just light.

For half a century, scientists have known that exposure to certain wavelengths of light can stimulate cellular function. In 1967, the Hungarian researcher Endre Mester attempted to treat cancerous tumors in rats with a low-power ruby laser. The cancer was unaffected, but the rats treated with the light waves experienced accelerated hair growth and wound healing.

Today, LEDs have replaced lasers, but researchers continue to investigate the curious health benefits of shining light on the body through a treatment method known as "photobiomodulation," or PBM.

PBM is slightly different than the technique used in the MIT study, in which researchers shined pulsed blue light into the eyes of mice in an attempt to reboot the brain's "gamma oscillation," the electrochemical frequency by which healthy neurons communicate.

With PBM, researchers use special headsets equipped with LEDs to shine pulsed red and near-infrared light on the outside of a patient's head and up through their nose. As with the MIT results, preliminary data suggest that photons of light passing through the skull trigger a biochemical chain reaction in the brain that can potentially reverse the degenerative effects of Alzheimer's as well as treat a range of other brain maladies.

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Michael Hamblin is a professor of dermatology at the Harvard Medical School and a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital. He co-authored a recent study in which dementia patients with serious cognitive deficits experienced swift improvement after just 12 weeks with the VieLight Neuro, an LED headset that shines pulsed near-infrared light on five targeted areas of the brain.

The VieLight Neuro device. Credit: VieLight

"These are people who haven't been able to speak in connected sentences for weeks or months who suddenly start having a conversation, speaking in full sentences, understanding and replying," Hamblin told Seeker. "People who had to be fed by caregivers can suddenly pick up a knife and fork and start eating their own meals. Remarkable changes."

Equally remarkable were the changes that occurred after the light treatments were stopped. The cognitive and behavioral benefits reversed almost immediately. The study called for a four-week period in which light treatments were suspended, but one patient's symptoms returned with such force that his family begged for the device back.

Scientists like Hamblin believe that PBM works by stimulating the mitochondria within cells to produce more ATP, the energy that powers cellular activity.

"The mechanisms are manifold," Hamblin explained. "Clearly you're boosting metabolism - ATP, oxygen consumption, brain energy. You're improving cerebral blood flow. But you're also stimulating the formation of new brain cells and the formation of new connections between existing brain cells. And together, these two processes comprise neuroplasticity, basically the brain's ability to reorganize itself, to repair itself."

 

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Margaret Naeser, a research professor of neurology at the Boston University School of Medicine, studies the use of PBM headsets and helmets to treat patients with traumatic brain injuries, stroke, and military veterans suffering from Gulf War Syndrome - an unexplained illness seen among those who fought in the 1991 Gulf War that can involve dizziness, insomnia, fatigue, and headaches, among other symptoms.

Naeser is in the middle of a $2.8 million study for the U.S. Department of Veterans Affairs to improve cognition and memory in vets using LED treatments. She explained that red light at 600 nm wavelengths and near-infrared light at 810 nm or 830 nm is absorbed by an enzyme inside cellular mitochondria called cytochrome c oxidase (CCO). In patients with brain injuries or disorders, the receptors on the CCO enzymes become clogged with nitric oxide.

"When you deliver near-infrared photons to that brain cell, the nitric oxide is pushed outside the cell wall, and that promotes increased blood flow, which is what you want in an area that's damaged," said Naeser. "And that's what we see on our MRI images, the increase in blood flow targeted to where we put the photons. I couldn't believe it. I was shocked."

In addition to priming blood flow in the brain, light treatments seem to boost the brain's autoimmune response to amyloid beta, the proteins that form the crippling plaque deposits found in Alzheimer's. In a healthy brain, immune cells called microglia are tasked with clearing out excess amyloid beta. In an Alzheimer's brain, microglia undergo a dangerous transformation. They not only stop attacking amyloid beta, but secrete a toxin that damages healthy brain cells.

In the MIT study, repeated exposure to blue light pulsing at the gamma frequency (40 Hz) appeared to train the Alzheimer's brain to return to its normal rhythm. In turn, it caused the microglia to return to their healthy state and start clearing out amyloid beta debris.

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Naeser explained that PBM light treatments use a different pathway to fight amyloid beta - sleep.

"You and I are building up amyloid beta all day," said Naeser. "When you go to sleep at night, the cerebrospinal fluid comes in and massages the cells in the brain to pull out amyloid beta buildup, get it into the blood vessels and wash it away."

Dementia patients sleep terribly, which disables the body's natural ability to clear out amyloid beta. Naeser noted that red and near-infrared light increase melatonin levels, and that caregivers of dementia patients receiving PBM treatments reported that the therapy greatly improved their sleeping habits.

Credit: VieLight

So far only a handful of small studies have put PBM to the test in treating Alzheimer's, stroke, PTSD, depression, and other brain-related disorders. The preliminary results are very promising, but Lew Lim, the founder and CEO of VieLight, said that larger and more rigorous clinical trials are needed before the FDA will approve such devices for medical use.

"Right now the VieLight Neuro is considered a general wellness device," said Lew. "For us to make a claim for Alzheimer's disease, we have to do big clinical trials. If we don't do that, the mainstream medical community is going to say it's another snake oil remedy."

Naeser, who has spent decades researching non-invasive medical treatments, including acupuncture and transcranial magnetic stimulation, said that the only way to legitimize PBM is by conducting double-blind studies that control for the placebo effect, which her current V.A. study does. Vets who sign up for the study will receive both real and "sham" treatments, and nobody - including the researchers - will know which was real or fake until the trial is complete and the data are analyzed Credibility and acceptance are likely to be the biggest obstacles facing widespread adoption of PBM. Ironically, the almost shocking simplicity and non-invasiveness of the treatments - shining light on the head for 20 minutes at a time - could be its undoing.

 

"In North America, if you're not a drug, you're probably not credible," said Lim. "One of the reasons that there are no big companies involved with PBM is because a lot of it is not patentable. We're one of the few with patents on this technology."

Hamblin from the Harvard Medical School said that he could see the day when every household will own at least one PBM device. He already owns several himself to help with memory, eyesight, and even hair growth. In the short term, though, there will be challenges to funding the types of studies required for PBM to compete with conventional drug therapies.

"Poor old light therapy is like a tiny grain of sand compared to the huge boulder of big pharma," said Hamblin. "Their business model has created a billion-dollar market. How do you make a billion-dollar market out of LED light devices?"

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/table/T4/?reportbjectonly


HowDoYouDeal
Posted: Friday, April 5, 2019 8:32 AM
Joined: 2/17/2019
Posts: 177


Wait, I may be wrong, I think these are manufacturer's trials, so they are not double-blind and the people treated could be experiencing a placebo affect because being part of the test makes them feel like they are being treated, and produce a temporary result, which then fades when they are no longer part of the study.

and there could be perception bias, because of course the people who make the product want it to work.  And there is always the possibility of companies being completely unscrupulous, I don't believe that's the case here, but.... there is a reason clinical trials take so long and are so expensive, they are really frickin' meticulous in terms of remove potential for 'white coat effect', perception bias or causation/correlation errors.

I still think that red light therapy and Near Infrared Light and Infra Red therapies are doing alot more than we think that light can do.



Lane Simonian
Posted: Friday, April 5, 2019 9:33 AM
Joined: 12/12/2011
Posts: 4545


You may be right on all of this.  The use of different wavelengths have different effects.  Some may have the potential to help those with Alzheimer's disease.

Visible red and infrared light alters gene expression in human marrow stromal fibroblast cells.

Different wavelengths and energy densities produced unique sets of genes identified by microarray analysis. Pathway analysis pointed to TGF-beta 1 [tumor growth factor-beta1] in the visible red and Akt 1 in the infrared wavelengths as key pathways to study.


Role of TGF-beta signaling in the pathogenesis of Alzheimer’s disease

We discuss that changes of TGFbeta-mediated regulation could at least partially mediate age-associated microglia changes, and, together with other changes on inflammatory response, could result in the reduction of protective activation and the potentiation of cytotoxicity of microglia, resulting in the promotion of neurodegenerative diseases.

Direct pharmacological Akt activation rescues Alzheimer's disease like memory impairments and aberrant synaptic plasticity.

 

Another one of interest:

Therapeutic ultrasound protects HUVECs [human umbelical vein endothelial cells] from ischemia/hypoxia-induced apoptosis via the PI3K-Akt pathway

 

The damage to the phosphatidyinositol 3-kinase is one of the critical factors in Alzheimer's disease.  Without its activation of AKT, neurons and synapses cannot be regenerated in the hippocampus and blood flow and the transport of glucose decline (leading to delusions).  Anything that can reverse damage to the phosphatidyinositol 3- kinase (cbd oil, other essential oils via aromatherapy, panax ginseng) or can directly activate Akt can likely help in the treatment of Alzheimer's disease.


HowDoYouDeal
Posted: Sunday, June 30, 2019 10:45 PM
Joined: 2/17/2019
Posts: 177


Thank you for the links to research Lane, your understanding of the science is amazing. This community is very lucky to have you.