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Dementia pathology
Posted: Wednesday, May 6, 2020 3:56 PM
Joined: 8/12/2019
Posts: 35

I have read an article about affected brain regions of FTLD and AD.
It says that 94% of Alzheimer’s patients have a tempoparietal hypometabolism with a sensitivity of 93% and a specificity of 50% does anybody of you know what these terms mean?

Posted: Tuesday, June 2, 2020 2:15 PM
Joined: 2/17/2019
Posts: 336

I asked Startpage (like google) and found this:  I've typed them out below to make them easier to read. (beware typos)" a condition (as in myxedema or hypothyroidism) marked by an abnormally low metabolic rate"


 "Another characteristic of AD is regional hypometabolism in the brain. This decline in cerebral  glucose metabolism occurs before pathology and..."


from here:  what is hypometabolism




  From a link that explains sensitivity and specificity in medical tests...



Another everyday example

Airport security offers a good example how these tradeoffs play out in practice. To ensure that truly dangerous items like weapons cannot be brought on board an aircraft, scanners at a security checkpoint may also alarm for harmless items like belt buckles, watches, and jewelry. The scanner prioritizes sensitivity and will flag almost anything that seems like it could be dangerous. But that means it also has low specificity and is prone to false alarms; a positive result is much more likely to be a shampoo bottle than it is an explosive device.


The same issues crop up when it comes to testing for deadly diseases like cancer. High sensitivity is desirable: missing cases of actual cancer could lead to delays in treatment that negatively affect outcomes. However, specificity is more important with cancer testing than it is at an airport checkpoint: false-positive results create anxiety and lead to unnecessary and invasive follow-up tests like biopsies. They raise costs for everyone involved and increase the likelihood of experiencing harm. Those harms can be significant enough to outweigh the potential benefits of the test.  (Prostate specific antigen [PSA] testing is a good example low specificity test that generates many false-positive results.)"


Posted: Wednesday, June 3, 2020 5:21 AM
Joined: 5/22/2020
Posts: 9

So if the sensitivity is 50% what exactly does that mean?