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Resveratrol Clinical Trial Seeking Participants
Posted: Tuesday, July 17, 2012 11:22 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

Source: Alzheimer's Assn.) - A multi-state clinical trial sponsored by the National Institute on Aging and Alzheimer's Disease Cooperative Study is seeking participants with mild to moderate dementia.

The purpose of this study is to determine whether daily resveratrol therapy is beneficial in delaying or altering the deterioration of memory and daily functioning in people with probable Alzheimer's disease.


Resveratrol is derived from plants and is found in red wine and the skin of red grapes. A recent study reported that monthly and weekly consumption of red wine is associated with a lower risk of dementia. There is compelling evidence that caloric restriction can improve overall health by activating a class of enzymes known as sirtuins. Resveratrol is a substance found in some plants that directly activates sirtuins, mimicking the effects of caloric restriction. It may also affect regulatory pathways of diseases of aging, including Alzheimer's disease.


In this study, 120 participants with mild to moderate dementia due to probable AD will be randomly assigned to treatment with either Resveratrol starting at 500 mg once daily or matching placebo for 12 months. The dose will be increased at 13-week intervals to a maximum of 1 gram twice daily.


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