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A Mushroom That Improves Your Memory and Mood?
Posted: Wednesday, August 8, 2012 10:35 PM
Joined: 12/6/2011
Posts: 3326

From Alzheimer's Daily News:

(Source: Huffington Post) - Mushrooms provide a vast array of potential medicinal compounds. Many mushrooms - such as portobello, oyster, reishi and maitake - are well-known for these properties, but the lion's mane mushroom, in particular, has drawn the attention of researchers for its notable nerve-regenerative properties.

Lion's mane mushrooms are increasingly sold by gourmet food chains. This nutritious mushroom is roughly 20 percent protein, and one of the few that can taste like lobster or shrimp.


Lion's mane mushrooms are increasingly studied for their neuroprotective effects. Two novel classes of Nerve Growth Factors (NGFs) have been discovered in this mushroom.


About a dozen studies have been published on the neuroregenerative properties of lion's mane mushrooms since 1991, when Dr. Kawagishi first identified NGFs in Japanese samples. Since his original discovery, in vitro and in vivo tests have confirmed that hericenones and erinacines stimulate nerve regeneration. In 2009, researchers at the Hokuto Corporation and the Isogo Central and Neurosurgical Hospital published a small clinical study. Giving lion's mane to 30 Japanese patients with mild cognitive impairment resulted in significant benefits for as long as they consumed the mushrooms.


Recently, mice were injected with neurotoxic peptides in an experiment to assess the effects of lion's mane on the type of amyloid plaque formation seen in Alzheimer's patients. The mice regained a cognitive capacity comparable to curiosity, as measured by greater time spent exploring novel objects compared to familiar ones. And the reduction of beta amyloid plaques in the brains of mushroom-fed mice was remarkable.


The influence of lion's mane influence on neurological functions may also have other added benefits -- making you feel good.


This data is not conclusive, yet it does suggest positive benefits of lion's mane.

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Posted: Thursday, November 14, 2013 11:58 AM
Joined: 9/13/2013
Posts: 112


  Below is the study of Lion’s Mane mushroom (Hericium erinaceus) referred to in the article:  


Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.  (Feb 2011) PMID: 21383512 



The mushroom Hericium erinaceus has been used as a food and herbal medicine since ancient times in East Asia. It has been reported that H. erinaceus promotes nerve growth factor secretion in vitro and in vivo. Nerve growth factor is involved in maintaining and organizing cholinergic neurons in the central nervous system. These findings suggest that H. erinaceus may be appropriate for the prevention or treatment of dementia. In the present study, we examined the effects of H. erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Mice were administered 10 µg of amyloid β(25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. Memory and learning function was examined using behavioral pharmacological methods including the Y-maze test and the novel-object recognition test. The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide. This finding indicates that H. erinaceus may be useful in the prevention of cognitive dysfunction. 


The news article reiterated that  This data is not conclusive, yet it does suggest positive benefits of lion's mane.   


There are some out there that have boldly tried it and believe that it works. An example is Ms Ethel Lord, an advocate of 'Alzheimer’s Coaching' method who runs a business of alzheimer’s coaching. She has stated the use of lion’s mane.  




I am tending to believe that this Lion’s Mane mushroom is beneficial. 


I would like to hear from anyone who has tried Lion’s Mane mushroom and provide any anecdotal evidence they can share.   



Lane Simonian
Posted: Friday, November 15, 2013 11:52 PM
Joined: 12/12/2011
Posts: 5173

Both reishi (Ganoderma Lucidum) and Lion's mane mushrooms inhibit the phosphorylation of p38 MAPK and it is the phosphorylation of p38 MAPK that leads to peroxynitrites and Alzheimer's disease. 


It is not surprising then that the findings for reishi mushrooms in the treatment of Alzheimer's disease is very similar to that of Lion's mane. 


Preliminary investigations in Japan of Reishi in the treatment of "environmental" stress-induced neuroses found that from 50 g thrice daily, the freeze-dried (liquid culture grown) mycelium proved of significant benefit to patients with psychological stresses.( 15) An eight-month study of Alzheimer's disease patients on the same mycelial product also found significant results.( 16) The latter application coincides with centuries-old uses where Chi zhi was prescribed to increase "intellectual capacity and banish forgetfulness," and when a patient displayed "listlessness."( 6) 


The failure to follow up on clinical trial results and anecdotal reports is really a great tragedy.