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So sorry for your loss. My thoughts and prayers are with you.
Welcome to the ALZ Connected forum! I think you will find plenty of experience and information for you and your family. If no one knows if she is taking her meds, eating properly, paying her bills, etc. - someone needs to look in and see. Does she have any siblings to help her?
I am going to try to put this in the simplest terms possible. The phospholipase C activation of protein kinase C which in a lipid raft environment leads to the activation of p38 MAPK, the formation of peroxynitrites, the nitration of NMDA receptors, the further activation of p38 MAPK, and the further formation of peroxynitrites is the cause of Alzheimer's disease. Everything else is either connected to this cycle or peripheral to it. This includes but is not limited to the amyloid precursor protein, amyloid oligomers, amyloid plaques, hyperphosphorylated tau, SorL1 gene dysfunction, REST dysfunction, and retromer dysfunction. Intervene at the early part of the cycle and you delay the onset of Alzheimer's disease. Intervene in the latter stage of the cycle and you effectively treat Alzheimer's disease.
I’m always looking for activities I can
do with mom so I can help her feel involved. One thing that works well is folding
towels and clothes (there’s a never-ending supply!). I also have her tear lettuce
and snap green beans – things that she can do by touch. None of it has to be perfect,
and it passes the time.
3420 people say this is good advice
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