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I Have Alzheimer’s or Another Dementia
i spent the day yesterday with university researchers
who have developed what i call an alzheimer worm
bexarotene prevented them from developing alzheimers
also other drugs have bee used that may be successful
you can read my thoughts on the visit on my blog
the organicgreen doctor
Welcome to our spacer. Please keep coming back.
I'm interested in more information on the scanning study you're involved in. How long have you been involved? Are you still considered MCI?
How capable do you feel you are, or do you find yourself slipping or increasing your cognition?If they share results of your scans with you, how does what the scans show correlate with how you are feeling?
And that test with blocks, I recognized. Could do the first few easily. Then just give me a few more minutes. I know there's a way I can turn it so it will match the model.
And I realized that test had nothing to do with memory.
Please stay with us. We need you. There are several of us regulars here who have been coping for quite a few years.
the worms are exciting because the gene that is inserted is suppressed
from making proteins which cause nerves to degenerate
just like in humans who get alzheimers
the worms only live 7 days so within three days of adding a medicine
the researchers will know it it works to prevent this nerve damage
many drugs or chemicals can be easily used and if they work
(they know in three days) then more work can be done in
mammals and eventually humans
the baroxetene worked in the worms then works in rats and '
will be tested in clinical trials next year
think of these worms as a screening test for potentially effective
treatments for alzheimers
to answer your question
i was diagnosed with mci two years ago and have seemed to
be stabilized. i am on aricept (donepezil).
my diagnosis was discovered by accident when i volunteered to
be a normal study subject in the adni study. luckily i had had a
good screen two years previously that was normal
the study evaluation showed short term memory loss that was new
in the study i get the beta amyloid pet scan and spinal fluid tests
for beta amyloid and tau protein, and blood tests and genetic tests
i dont get to ever see these results
i have had mri scans, glucose metabolism pet scans and other lab work
that i get the results of
i on my own had genetic tests done-i carry the apoe 4 homozygous gene
spinal fluid for tau and beta amyloid-are borderline abnormal
my mris and glucose metabolism tests are all normal
soon i will be getting the amyvid pet scan (for beta amyloid)
the adni study is probably going to be a long term study
i also will have my human genome done but will not get the results
This is fascinating research done at University of Texas, Austin. I say God Bless Texas and the Alzheimer's worm!!
I will be sure to follow this. Thank you.
Of course, I used to think I keep up on research and after reading your post I realize how little I know.
The important thing is you seem to have stabilized.
And I do understand that we must have long term studies to understand the progression of the disease.
I'm wondering if some of those scans you have seen the results of, one can tell what the progression of the disease is. In other words, by looking at a scan, can a professional tell what you should be capable of?
the scans that are done are like a brain thats autopsied at death
the amount of changes seen on the scans that are abnormal dont
always correlate with the amount of symptoms a person has
some people die with few symptoms but their brains when autopsied
will show more advanced disease than expected
but generally if your mri scan shows brain shrinkage and your
glucose metablolism test shows decreased glucose uptake and
your beta amyloid pet scan of the brain shows a large amount of
plaque formations in the brain then you will usually have
medicine is at the beginning of all of this and how all these are used
along with the blood test for proteins and biomarkers and spinal fluid
analysis will be defined in the near future
now we need a treatment or prevention when these abnormalities are found
in my case i have both parents who had the disease and a younger brother
who has the disease
i had a normal mental status evaluation that changed over two years
documented on neuropsychological tests
i have normal evaluations for other causes
i carry the double apoe 4 genotype which is associated with increased
risk for developing alzheimers disease
i have borderline levels of beta amyloid and tau protein in the spinal fluid
but i have a normal mri brain scan and a normal glucose metablolism
add this all up
i probably have alzheimers disease but im very early so some of
these tests have not turned positive yet
its likely when i have the amyvid or beta amyloid pet scan that i have
done privately that the amyloid plaques will be present
right now thats as good as you can do in making a diagnosis
of course time will eventually be the final test
will show more advanced disease than expected THIS IS PUZZLE THAT I WONDER WHERE WE ARE IN SOLVING.
but generally if your mri scan shows brain shrinkage BY THE TIME THIS SHOWS ONE IS USUALLY PRETTY FAR ALONG and your
glucose metablolism test IS THIS THE PET, PITTSBURG COMPOUND TEST? shows decreased glucose uptake and
THERE SEVERAL OF US HERE, WHO BY THE VIGOROUS PRACTICE OF BEST PRACTICES SEEM TO BE DELAYING THE MAJOR WORSENING OF SYMPTOMS.
WE HOPE SOMEDAY TO BE PART OF AN INVESTIGATION TO SEE WHETHER THERE IS ACTUALLY AN EFFECT OR IF IT'S JST THE VARIABILITY OF AD FROM PATIENT TO PATIENT.
IN ORDER TO DO THIS, WE NEED A LARGE NUMBER OF PEOPLE DIAGNOSED VERY EARLY AND FOLLOWED LONG TERM.
I WOULD NEVER AGREE TO BDE THE PART OF THE CONTROL, BUT THERE ARE PEOPLE WHO SHRUG AND REFUSE TO CHANGE THEIR LIFE STYLE. THEY COUD ACT AS CONTROLS.
who has the disease HAVE YOU READ ABOUT THAT NEW GENE JUST ID'D WHERE THE POTENTIAL IS MUCH WOSE THAN APOE4
I NEVER HAD THE SPINAL TAP AND MY MRIS ARE NORMAL. I THINK I HAVE HAD NORMAL MRI'S WITH CONTRAST AND I UNDERSTAND THAT A FUNCTIONAL MRI IS THE BEST TO SHOW RESULTS.
IF YOU CAN BREAK YOUR WRITING INTO VEFRY SHORT PARAGRAPHS, IT MAKES IT EASIER FOR MANY OF US TO READ.
the amyvid or beta amyloid pet scan is like the pittsburgh compound scan
the glucose metabolism test uses a labeled glucose molecule
best practices-mediterranean diet, exercise, adequate sleep, staying mentally active, controlling your blood pressure and cholesterol, controlling you depression
will prevent or slow down this disease
i think studies are ongoing now looking at this
we all should be doing this anyway
the new gene is rare as are most genes that are associated with alzhiemers
even the apoe 4 genotype represents a small portion of those with
most cases of alzheimers have multiple causes
the organicgreen doctor