Loading discussion content. Please wait...
Low Intensity Focused Ultrasound Pulse- AD- UCLA
Participants will then be administered four successive LIFUP
treatments while the participants are in a functional magnetic
resonance imaging (MRI). Sixty minutes following the administration,
participants will undergo a second neuropsychological test. A final
follow-up assessment will be administered at one week.
Recently there have been multiple reports that DBS of different
locations within the brain may be effective in improving symptoms
characteristic of dementia (e.g., Heschman et al., 2013).
Laxton et al. (2010) performed DBS in the fornix/hypothalamus of six
persons with AD in a phase I clinical trial. The investigators
hypothesized that stimulation of the fornix would alter the activity of
the medial temporal memory circuits, and thus delay and/or reverse
After 6-12 months, the investigators noted improvement or
slowing in the progression of AD in some of the research participants,
as measured by two commonly-used assessments of global cognitive
In a recent literature review, Laxton et al. (2013) also
described several additional studies demonstrating that DBS of the
fornix or nucleus of Meynert or subthalamic nucleus influences the
pathologic neurological circuits involved in AD.