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Treatment in Toronto for Dementia with Agression
HowDoYouDeal
Posted: Sunday, November 24, 2019 9:01 PM
Joined: 2/17/2019
Posts: 347


Trial record 9 of 35 for:    pulsed brain | Alzheimer Disease

Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS (tTED)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT03846492
Recruitment Status : Recruiting
First Posted : February 19, 2019
Last Update Posted : August 15, 2019
Sponsor:
Collaborator:
BrightFocus Foundation
Information provided by (Responsible Party):
Sanjeev Kumar, Centre for Addiction and Mental Health
 
Study Design
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Study Type : Interventional  (Clinical Trial) Estimated Enrollment : 90 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: Individuals with AD + agitation will receive a 2 week course of active/sham cathodal tDCS to frontal brain region in a double blind 1:1 randomized control design. Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS Actual Study Start Date : April 24, 2019 Estimated Primary Completion Date : June 2022 Estimated Study Completion Date : June 2022

HowDoYouDeal
Posted: Sunday, November 24, 2019 9:08 PM
Joined: 2/17/2019
Posts: 347


https://clinicaltrials.gov/ct2/show/NCT03846492?term=pulsed+brain&cond=Alzheimer+Disease&draw=3#contacts

 Experimental: Active tDCS

The direct current will be delivered at 2 mA intensity via rubber electrodes in saline- soaked sponges for 30 min per day for 2 weeks, 5 days/week. Inhibitory stimulation will be delivered to the frontal lobes.
Device: Transcranial Direct Current Stimulation (tDCS)
 
tDCS is a non-invasive brain stimulation modality that does not require general anesthesia or surgical implantation of a device.
 
 tDCS utilizes low intensity electrical current either to increase cortical excitability with an anodal electrode or to suppress cortical excitability with a cathodal electrode.
 
  It uses 3 AAA batteries to deliver direct current via rubber electrodes enclosed in saline soaked sponges.
 
Sham Comparator: sham tDCS
Sham tDCS will use the same parameters except that the device will automatically turn off after a certain duration.
 
Intervention Model Description: Individuals with AD + agitation will receive a 2 week course of active/sham cathodal tDCS to frontal brain region in a double blind 1:1 randomized control design.
 
 

 
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