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For Myriam, iris and anyone else interested in research questions
Mimi S.
Posted: Wednesday, July 18, 2012 4:44 PM
Joined: 11/29/2011
Posts: 7027


An intriguing question has been going round my brain.

 

The experts say that the only true diagnosis of dementia can be made after death by an autopsy. We are pretty sure that those diagnosed after the gold standard procedure do have the disease. I suppose Iris, that you'll need to peer from above to see what your actual diagnosis was.

 

Then I happened to recall that famous nun's experiment. Is it still ongoing? At autopsy there were a certain amount of nuns who were apparently normal, but showed amyloid in the brain at autopsy.  

 

So, my theory is: if the Pittsburg compound PET scan  or spinal tap test had been available and given to those nuns during their lifetime, they would have showed the markers. It was probably their superior cognitive reserve (otherwise known as high IQ) that gave them the coping skills not to have their impairment become evident.

 

Then I came across this today

http://www.alzheimersreadingroom.com/2012/07/anti-amyloid-treatment-of-asymptomatic.html?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+TheAlzheimersReadingRoom+%28Alzheimer%27s+Reading+Room%29  (sorry, couldn't figure out how to make this an attachment.)

 

Read /listen carefully. Too bad I couldn't stop the video and save those charts for further study.

  

Comments, please. 


Myriam
Posted: Wednesday, July 18, 2012 10:02 PM
Joined: 12/6/2011
Posts: 3326


Thank you, Mimi. Verrrry interesting video. I'm excited about all the new research. 

 
About the nuns. I have a theory. As you know, their lives are simple and regimented. They also spend a great deal of time in prayer or meditation. I believe their symptoms were not evident because they did not face the stresses and chaos of daily living in our society.   

 
As you know, I have a genetic form of EOAD.  My father, 5 or 6 of his siblings, and 2 out of 4 of my oldest cousins all showed symptoms of AD in their 40's and early 50's. I've spent many years practicing meditation and my first symptom appeared when I was 63. I don't know if it's cause and effect, but I believe it is. 

Iris L.
Posted: Thursday, July 19, 2012 12:34 AM
Joined: 12/15/2011
Posts: 18219


Mimi S. wrote:

 So, my theory is: if the Pittsburg compound PET scan  or spinal tap test had been available and given to those nuns during their lifetime, they would have showed the markers. It was probably their superior cognitive reserve (otherwise known as high IQ) that gave them the coping skills not to have their impairment become evident.

 

  


I think this is true with a caveat.  High IQ people  are able to think of work-arounds their cogntive impairments to a certain degree.  But when that line is passed, the patients are accused of behvioral difficulties, substance abuse or other socially unacceptable traits as a cause of their strange behavior.  I've been in this position.

Here is a direct link to the story and video;
 

http://www.alzheimersreadingroom.com/2012/07/anti-amyloid-treatment-of-asymptomatic.html?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+TheAlzheimersReadingRoom+%28Alzheimer%27s+Reading+Room%29

Iris L. 


Mimi S.
Posted: Thursday, July 19, 2012 9:55 AM
Joined: 11/29/2011
Posts: 7027


And the high IQ may be what's holding back their actual diagnosis. Possibly when the spinal tap or Pittsburg compound PET are more readily available, more of this high performing individuals can be identified. 

 

I don't know if either of the above two will give clues to the type of dementia. 

And so another question. Do the PET (Pittsburg Cmpd) scans of people at the same stage, but with differing dementia diagnoses differ?


Geegee
Posted: Thursday, July 19, 2012 12:37 PM
Joined: 11/29/2011
Posts: 514


Mimi, very interesting and encouraging video.  Thanks for sharing.  Also, I continue to learn from all three of you. 

 

Oh Mimi, FYI:  This might help you post links you are referring to.  When you are typing your Message under Add reply, look below the white square space to the purple  "Attached Files".  There is a green  box marked "Attachments."  When you select that, you can paste your site information.  It automatically is formatted for you.

I think that's what you were needing when you posted the link. 

 

 Iris, is that what you did?


Iris L.
Posted: Thursday, July 19, 2012 12:54 PM
Joined: 12/15/2011
Posts: 18219


No, Geegee, what I do is go to the website, copy the address, and then paste into my message.  I hit the space bar once and the website address automatically becomes highlighted. 

Sometimes I have to backspace to the right spot, before I can hit the space bar.

Formatting is still tough.

Iris L.

Mimi S.
Posted: Thursday, July 19, 2012 8:39 PM
Joined: 11/29/2011
Posts: 7027


Gee-gee I did it the way you said. I'm trying to do it that way. I did remember and it wouldn't work. It acted as if i had to choose something from my own computer! 

Sometimes there are so many bells and whistles that they forget some of us are challenged.

 

Years ago, shortly after I joined, something new was added and we all had to reregister and were not allowed to reuse the old password. I protested that I had one password that I could remember and that was it.

 

I got an immediate reply. Of course. And we were allowed to use our old passwords. Those who understood were heard!


Geegee
Posted: Friday, July 20, 2012 7:04 AM
Joined: 11/29/2011
Posts: 514


Yep! too many bells and whistles!

I've tried it Iris' way and sometimes it works and other times not.

 

I copy and paste into the attachment box.

 

Mimi, it looks like you did just exactly what Iris does. ??? and it didn't work for you.

Who knows?!  No worry, we always find it anyway!


Iris L.
Posted: Friday, July 20, 2012 8:23 AM
Joined: 12/15/2011
Posts: 18219


Mimi S. wrote:

Gee-gee I did it the way you said. I'm trying to do it that way. I did remember and it wouldn't work. It acted as if i had to choose something from my own computer!  


Mimi, you are right.  When you use Attachments, the computer wants you to attach a document or photo from your own files.  That's the way that works. 

 

Copy and paste will enable you to copy and insert website addresses.
 

But don't worry, if I see your posts, I'll copy and paste for you.  No problem!

Iris L.
 


bela
Posted: Thursday, October 18, 2012 4:32 AM
Joined: 12/15/2011
Posts: 4122


how does one make the url/link blue so readers can just click on the link which takes you to the article?
Lane Simonian
Posted: Thursday, October 18, 2012 11:36 PM
Joined: 12/12/2011
Posts: 5130


Right click next to the url you want to post, then left click on copy.   Then right click again where you want to post it and left click on paste (or sometimes a block comes up asking if you wish to allow access which you can then agree to). 
 
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