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List of Alzheimer's drugs in clinical trial (2017)
Lane Simonian
Posted: Monday, September 11, 2017 6:11 PM
Joined: 12/12/2011
Posts: 3984


The following link provides a list of the some one hundred drugs in clinical trials for Alzheimer's disease as of the beginning of this year.

http://www.sciencedirect.com/science/article/pii/S2352873717300379

There is unfortunately not much diversity in approach.  A few of these drugs may slow down the progression of Alzheimer's disease.


Keep It 100
Posted: Friday, September 15, 2017 1:59 PM
Joined: 2/26/2017
Posts: 83


Sadly, one big takeaway from this article, is the unfortunate low volunteer rate for drug trials. Often the recruitment period is so drawn out, that it exceeds the actual treatment period time frame, and some trials may never get completed. 54,000 total volunteers (from pre-symptomatic to mild/moderate alz) are needed to fill the current pipeline. 

Ray is in a phase II trial for a cancer drug being repurposed for Alz and Parkinson's. The Alz arm only needs 42 volunteers, and at nearly one year of recruitment, there are currently only 11 enrolled. 

I know that in the case of Ray's trial, the main challenges are that it is only at a single site, and that particular site, Georgetown, is a challenge to get to, park, etc. It can be a big hassle for us, but we really enjoy the research team, and love all of the medical attention Ray gets. Besides transportation/access and proximity to the site...what are other reasons for low participation overall?

The primary reason we participate is that it gives us a sense of doing something to help the overall scientific community solve this puzzle. A miracle cure for us? Ray likes to think so, so it gives him hope, along with a purpose. But no, I am not naive enough to think that is so. But every bit of knowledge gained is hopefully moving the needle and doing something ultimately for all of us.


 
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