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NMDA receptors and CBD oil
I am almost certain that the following is the correct pathway and the route to effectively treating Alzheimer's disease:
We suggest that oxidative stress mediated through NMDAR and their interaction with other molecules might be a driving force for tau hyperphosphorylation and synapse dysfunction. Thus, understanding the oxidative stress mechanism and degenerating synapses is crucial for the development of therapeutic strategies designed to prevent AD pathogenesis.
The potential for CBD oil (and panax ginseng with ferulic oil and essential oils with eugenol through aromatherapy) fit perfectly into this hypothesis.
Voltage-dependent dysregulation of intracellular Ca2+ homeostasis and/or calcium signaling and N-methyl D-aspartate (NMDA) receptor activation can potentially contribute to excitotoxicity, neurodegeneration, and memory impairment in the AD brain. Additionally, Aβ suppresses glutamate uptake by the brain cells that leads to excessive activation of glutamate receptors and cause excitotoxicity [peroxynitrite rather than amyloid is the direct cause of reduced glutamate uptake].
In vitro studies have shown that cannabidiol can reduce inducible nitric oxide synthase, NO production, inflammatory cytokines transcription factors, and stress-activated protein kinase p38 in AD models [some of the intermediate molecules between NMDA receptor activation and peroxynitrite formation].
By virtue, as a potent antioxidant, cannabidiol reduces lipid peroxidation and scavenges reactive oxygen species, independent of CB1 receptor. Cannabidiol reverses tau protein hyper-phosphorylation by inhibiting phosphorylation of a kinase molecule that is involved in tau phosphorylation and the progressions and worsening of AD.
CBD, THC, eugenol, and ferulic acid are all peroxynitrite scavengers. They reduce glutamate excitotoxicity, remove peroxynitrite, untangle tau tangles, increase the regeneration of neurons in the brain, and increase levels of neurotransmitters needed for the retrieval of short-term memory, sleep, mood, social recognition, and alertness.
The effective treatment of Alzheimer's disease is within sight.