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Ibuprofen vs montelukast (Singulair)
In early 2015, I began feeling a tremendous mental fatigue every day, and it was especially bad when focusing on solving a problem. I also had occasional confusion. Sometimes when walking or taking a taxi, I could not remember where I was going or why.
In 2015, after reading about some research on the NSAID Ibuprofin, I started taking it 3 times a day (I don't remember the dosage) for about 3 months. I quit taking it because I could not see any improvement. and because there are some serious risks with this drug long term.
After reading about Dr. Aigner's research using montelukast in animal research, I started taking 10 mg once a day (recommended dosage for prevention of asthma attacks). Within a few days, I felt my mental fatigue go away for about half a day. After switching to 10 mg twice a day, it went away completely. I later started taking 20 mg twice a day, and I have been taking it more than two years now, and I am completely back to normal.
Anti-inflammatory drugs, if they work, work right away and you can feel the improvement. For me, Ibuprofen did not work, and montelukast did and it also much safer for long term use. It was that simple.
Some results from the montelukast clinical trial for Alzheimer's should be available by the end of 2018 or beginning of 2019.
Hi Larry, I’m sure you’ve read about Dr. Praticòs work with Zyleuton (Zyflo):
I’ve been following your posts and see that you’ve had positive results with montelukast(Singulair). I’m hoping to get my Mom on Zyflo (will need Dr to prescribe off label), in the meantime we’ve started her on a 5 LOX Inhibitor.
Naproxen and acetaminophen can scavenge peroxynitrite but they can also increase peroxynitrite levels by increasing the release of intracellular calcium.
These data suggest a revision of the original ADAPT hypothesis that NSAIDs reduce AD risk, thus: NSAIDs have an adverse effect in later stages of AD pathogenesis, while asymptomatic individuals treated with conventional NSAIDs like naproxen experience reduced AD incidence, but only after 2 – 3 years. Thus, treatment effects differ at various stages of disease. This hypothesis is consistent with data from both trials and epidemiological studies.
Thanks, dolor. Another contradiction, tomatoes contain lycopene which is an antioxidant.
Cooking tomatoes may increase pro-inflammatory compounds, however.
The contradictions really use to get to me, but not so much anymore. The same compound can have different effects on different parts of the body, or can trigger certain pathways that are beneficial and others that are harmful, or can be safe at one dose and not at another, or can be safe for one person but not for another, or can be harmful at one stage of life but not at another. Often one substance contains multiple compounds which complicates things even more.
After fourteen years of studying Alzheimer's disease, I am still not completely at ease regarding the triggers, pathways, and potential treatments for the disease, but I am less befuddled and frustrated than I was before.
Dolor. Thanks for your interest. Even though monteukast is a very safe drug for long term use, the problem is getting a doctor to prescribe it. You can get a prescription for three months and then take 10 mg twice a day, or 20 mg twice a day for a couple of weeks. This is just to see if it shows a benefit. If it shows a benefit, then continue.
As far as the type of dementia, I think that any dementia due to aging would show positive results due to a reduction in inflammation.
Birdies. Thanks for informing me. I read another article earlier this week about Dr Pratico's work with Zyleuton. There are three drugs available in the US that inhibit leukotrienes - montelukast (Singulair), zafirlukast (Accolate), and zilenton (Zyflo). Montelukast and zafirlukast block inflammation causing leukotrienes from entering cells. Zilenton works differently. It interferes with the body's ability to make leukotrienes, and it has been found to have some serious side effects in some people. Therefore there is no need to consider using zilenton since montelukast and zafirlukast are both very safe for long term use. I have been using montelukast for over two years with no problems.
Dr. Aigner did animal research in 2015 and showed that rats with signs of dementia which were treated with montelukast were returned to normal. Dr. Pratico showed that mice with dementia treated with zilenton were returned to normal and that tau that was damaged in the brains of the mice began functioning normally again.
More importantly a clinical trial for the treatment of Alzheimer's using montelukast is going on now in Canada. We should see some results by the end of 2018 or the beginning of 2019.
Lane, Lane, Lane. Why are you stepping on my post? I first saw this post on Malinow about two years ago and you have kept posting it over and over. You seem to have a whole library of posts you keep sending out over and over. These are confusing posts with a lot of unsupported conclusions.
You are interfering with me telling my story. I am trying to give some practical info on a possible drug treatment for Alzheimer's and also about an ongoing clinical trial.
What you are doing is confusing people. Your thinking is just not clear because you jump to conclusions without any clear proof. It is very unscientific..
Lane, I have a degree in mathematics and consider myself a pretty smart guy. I took a lot of chemistry and biology in college. I don't claim to be a scientist, but I am educated enough to detect your scientific sounding b s. Exactly what are your qualifications, Lane.
If you want to comment on my post, please limit it to a few sentences. I don't need an incomprehensible scientific lecture, and I don't appreciate you taking over my post. Thanks.
Oops, Larry, it was really my fault. I jumped in with a dozen questions, sorry!
Next time, I'll attack Lane with questions on his own thread.
Hi Birdies. I am really not a grouchy old man. The only person that irritates me on this site is Lane, who is our resident pretend scientist. He (or she - not sure) irritates a lot of other people also.
I was diagnosed in early 2015 in Ghana with early stage age related dementia. I was experiencing extreme mental fatigue and occasional confusion, but I appeared normal to everyone. I started taking montelukast in early 2016 and I was back to normal, so I am lucky not to have spent much time with dementia. I am also fortunate that I live in a country where I don't need to have a prescription to buy the drug.
There is a Dr Rozin in Lawrenceville, GA, who did a study of patients that he treated with montelukast, and it appeared that patients from all stages benefited from the treatment. Over 90 per cent of the patients benefited in some way.
He prescribed 80 mg a day. I only take 20 mg twice a day, so I think 40 mg a day may be more reasonable. Montelukast has a very good safety record with long term use. Here is the web address of the study and also his website address.
Thanks and good luck.
The questions dolor asked were both relevant and important.
Providing the study on Montelukast and L-carnitine showed the potential value of using anti-inflammatories and anti-oxidants in tandem (although the study was for lung injuries and not Alzheimer's disease).
The other major area covered was the limitations of non-steroidal anti-inflammatory drugs and their sometimes damaging side effects.
My background is in environmental history, especially in Latin American environmental history. That includes an understanding of the effects of pollutants and other toxins on the environment and on human health, which now includes Alzheimer's disease.
I have taken a number of biology courses in areas such as ecology, conservation, and evolution and also a course which covered biochemistry. I started studying Alzheimer's disease fourteen years ago when my aunt and cousin were in the late stages of the disease and my mother was in the early stages of the disease. I began using aromatherapy three years later when my mother was in the later stages of Alzheimer's disease. With aromatherapy, she recognized her home again, could recognize objects, could remember her name, could remember phrases, had a better sense of time, and was more alert and aware.
I take the criticisms as they come even the very biting criticisms. What I know may some day be of value to my harshest critics.
I will go back to the truce. On another site I promised not to write anymore about Alzheimer's disease until there is a breakthrough. While I am not counting on it, I hope that Montelukast will be a breakthrough.
I have never claimed to be a scientist; only someone who has devoted many years to trying to understand Alzheimer's disease. Sometimes I repeat critical findings, sometimes I don't explain myself clearly, sometimes I devote too much time to complicated subjects, sometimes I make mistakes, sometimes I veer off into tangents. I have tried my best to understand Alzheimer's disease and to explain the science as clearly and as well as I can.
Hi Larry, when you started Singulair did you have any nightmares or other neuropsychiatric events (depression, aggression)?
Also; have you encountered any other AD or dementia patients on this site (or otherwise), that have benefitted from Singulair like yourself?
I asked Larry about the “nightmares - etc”, because they are one of the adverse effects of Singulair. I think mainly in children. Just google it.
I better clarify with Larry what i meant!
This is to clarify my last question:
Did you have any adverse effects like, nightmares-insomnia-etc when you started taking Singulair?
Is there any workaround for patients in the USA to get access to Montelukast if a doctor won't prescribe it for Alzheimer's since it is designated as an asthma medication?
I don't know if my LO's neurologist would be willing to prescribe the repurposing of Montelukast in this manner.
The chance that your neurologist will prescribe montelukast (Singulair) for Alzheimer's is slim to none. Neurologists have a very, very limited number of drugs that they can prescribe for Alzheimer's and dementia that are generally accepted by the medical establishment. They have a lot of very sick patients, and they are not going to stray from what is considered medically accepted, regardless of how safe or promising the drug is.
If you don't have a relative or personal friend who is a medical doctor, then I suggest you go see a family physician, GP, etc, who is not part of your plan and does not have access to your medical records. Tell him or her that you have taken montelukast before for asthma and want to start back. The standard dosage for asthma attack prevention is 10 mg once a day. Get about a 3 month supply or what ever you can get.
Try out the drug for about 2 weeks taking a minimum of one 10 mg tablet twice a day, or a maximum of two 10 mg tablets twice a day. Anti-inflammatory drugs work very quickly. If the patient shows improvement, then continue. If not, he or she can stop. Sorry, this is the only solution I can come up with, unless you want to leave the states. Good luck.
Will you post how the Montleukast is going with your DW?
I would like to get my Mom on it too.
Markus, I glad that you have found a way to get montelukast for your wife. I am sorry to hear that you have to pay such an outrageous price. I hope the overseas pharmacy will come through quickly. Here is hoping the US government doesn't intercept the package. The government seems to be working extra hard to protect big pharma monopolies in the US.
I still think the easiest way is to go to a family physician, GP, etc and say that you have taken this medication before for asthma, and he\she will write the prescription on the spot. Of course you may only be able to get a 10 mg per day prescription, so you have to go to multiple physicians and pay for multiple visits, so there is a big cost there too. But once you get the prescriptions, renewing is easy. Good luck to you and your wife.