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Feru-guard and Alzheimer's disease
I read the first study this morning and the second study this evening.
2020 Aug 6 (online ahead of publication)
In conclusion, the current study demonstrated the clinical effectiveness of ferulic acid and A. archangelica extract on cognitive functioning among older adult individuals with MCI.
Published: 18 September 2020
There is yet a third study that has been completed by the Oregon Science and Health University for the use of feru-guard to treat neuropsychiatric and behavioral problems in dementia--the results have to be released by the end of the year.
Am I reading it correctly that the findings of these two studies contradict each other?
I cannot effectively read studies any more, but am curious what might cause differing results, if I am reading it correctly.
I never did well in multivariate statistics, so I have always had to have research savvy friends explain such things to me.
You got it exactly right, KawKaw (I barely passed my statistics class, so I have to look for help from others, too).
I am trying to figure out what may account for the difference between the two studies. There may have been a difference in dose. The second trial (the positive one) was double-blinded so neither the patient nor the investigators knew who was getting the supplement whereas the first one was not (which could lead to more bias). The small numbers in both studies could lead to misleading conclusions (too many or too few people who were not going to convert to dementia in the first place or maybe more people taking other supplements or drugs in one group or another).
Over the years, the effects of feru-guard on neuropsychiatric and behavioral problems of dementia have been more consistent and more positive than for cognition. I am hoping that the Oregon Science and Health University will verify the former.